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Top 15 AI Development Companies in San Antonio, USA

Artificial Intelligence is reshaping industries across healthcare, finance, entertainment, and beyond. San Antonio is home to innovative firms leading this transformation with AI-powered solutions. Here are the Top 15 AI Development Companies in San Antonio (USA) worth exploring.

1. Jrs Innovative Retail Systems Inc

Headquarters: San Antonio, USA
Founded: 2015

Why They Stand Out: JRS delivers AI solutions that enhance retail, entertainment, and online experiences with strong cloud and web capabilities.

Key Strengths:

  • AI-powered retail systems
  • Cloud and web integration

Best For: Retailers and media companies seeking smarter digital engagement.

2. Miner Consulting LLC

Headquarters: San Antonio, USA
Founded: 2008

Why They Stand Out: Specializes in healthcare-focused AI and machine learning solutions with custom web development services.

Key Strengths:

  • Healthcare AI & ML development
  • AI-driven web applications

Best For: Medical organizations adopting predictive and AI-driven tools.

3. Avosys Decypher J V, LLC

Headquarters: San Antonio, USA
Founded: 1998

Why They Stand Out: Known for advanced analytics, cloud, and AI services across media, finance, and technology sectors.

Key Strengths:

  • AI for financial services and media
  • Cloud-driven analytics

Best For: Enterprises requiring large-scale AI integration.

4. Mirelco

Headquarters: San Antonio, USA
Founded: 1995

Why They Stand Out: Provides IT services, security, and cloud-based solutions with AI-enabled capabilities.

Key Strengths:

  • AI for IT security
  • Cloud hosting with intelligence layers

Best For: Small businesses seeking AI within IT infrastructure.

5. It Soft

Headquarters: San Antonio, USA
Founded: 1997

Why They Stand Out: Focuses on AI for big data and analytics, supporting organizations with high-volume data processing.

Key Strengths:

  • Big data + AI development
  • Custom analytics platforms

Best For: Enterprises needing AI for large data environments.

6. Computer Investing Consultants

Headquarters: San Antonio, USA
Founded: 1988

Why They Stand Out: Combines AI and data analytics for healthcare, media, and tech-focused web platforms.

Key Strengths:

  • Healthcare AI analytics
  • AI-enhanced media applications

Best For: Organizations requiring AI in healthcare and entertainment domains.

7. Trellis

Headquarters: San Antonio, USA
Founded: 2019

Why They Stand Out: Venture-focused firm using AI to empower startups and financial services.

Key Strengths:

  • AI in venture capital and finance
  • MVP development with AI

Best For: Startups and fintech firms leveraging AI for growth.

8. Sada International Services LLC

Headquarters: San Antonio, USA
Founded: 1976

Why They Stand Out: Experienced provider of AI and web development services, specializing in media and entertainment.

Key Strengths:

  • AI solutions for media businesses
  • Data-driven web platforms

Best For: Media and entertainment enterprises modernizing with AI.

9. Paredes Computer Designs

Headquarters: San Antonio, USA
Founded: 1949

Why They Stand Out: Long-standing company providing AI, big data, and analytics solutions for businesses of all sizes.

Key Strengths:

  • Big data & AI consulting
  • Custom analytics design

Best For: Organizations modernizing data processing with AI.

10. Denali Games LLC

Headquarters: San Antonio, USA
Founded: 2016

Why They Stand Out: Game-focused developer embedding AI into interactive experiences.

Key Strengths:

  • AI-driven game development
  • Entertainment-focused AI applications

Best For: Gaming and interactive media companies.

11. Data Concepts Inc

Headquarters: San Antonio, USA
Founded: 2015

Why They Stand Out: Specialists in AI-powered data management, analysis, and big data solutions.

Key Strengths:

  • Big data & AI integration
  • Custom AI analytics

Best For: Enterprises optimizing decision-making with AI.

12. Infinity Solutions, LLC

Headquarters: San Antonio, USA
Founded: 2000

Why They Stand Out: National staffing and services provider offering AI across healthcare, finance, and technology.

Key Strengths:

  • AI solutions for healthcare and finance
  • Broad industry expertise

Best For: Large enterprises requiring AI-enabled staffing and systems.

13. Hats Off Technology LLC

Headquarters: San Antonio, USA
Founded: 2011

Why They Stand Out: Health tech startup building AI-powered apps and digital transformation solutions.

Key Strengths:

  • AI in healthcare apps
  • Mobile AI solutions

Best For: Healthcare startups adopting AI for patient engagement.

14. Spotters LLC

Headquarters: San Antonio, USA
Founded: 2014

Why They Stand Out: Boutique firm offering AI-driven data analytics and web applications for media.

Key Strengths:

  • AI analytics & reporting
  • Custom AI-enhanced web development

Best For: Small businesses seeking affordable AI tools.

15. Rike Bros LLC

Headquarters: San Antonio, USA
Founded: 1988

Why They Stand Out: Provides AI-enabled cloud and web solutions for media and tech companies.

Key Strengths:

  • Cloud + AI integrations
  • AI for media platforms

Best For: Media and entertainment teams adopting cloud-based AI.

San Antonio’s AI Future is Bright

From retail AI platforms and healthcare-focused solutions to AI-driven gaming and analytics, San Antonio offers a diverse ecosystem of AI innovators. These 15 companies demonstrate how local expertise is driving global transformation in Artificial Intelligence.